Samfurin: 2-phenylacetamide
Tsarin kwayoyin halitta: C8H9NO
Nauyin Kwayoyin: 135.17
Sunan Ingilishi: Phenylacetamide
Hali: Farin flake ko lu'ulu'u masu siffar ganye.Mp 157-158 ℃, bp 280-290 ℃ (rubutu).Mai narkewa a cikin ruwan zafi da ethanol, mai narkewa a cikin ruwan sanyi, ether, da benzene.
Amfani: Tsakanin magunguna irin su penicillin da phenobarbital.Hakanan ana amfani dashi don shirye-shiryen phenylacetic acid, kayan yaji, da magungunan kashe qwari.
Hanyar 1) Masuko F, Katsura T.US 4536599A1.1985.
Ƙara 117.2 g (1.0 mol) na phenylacetonitrile (2), 56.1 g na 25% potassium hydroxide bayani, 291.5 g na 35% hydrogen peroxide bayani mai ruwa, 1.78 g na benzyltriethylammonium chloride, da 351.5 g na isopropanol zuwa dauki.Dama kuma amsa a 50 ℃ na 4 hours.Bayan da aka kammala dauki, isopropanol ne evaporated a karkashin rage matsa lamba, sanyaya, tace, wanke da ruwa, da kuma bushe don samun fili (1) 128.5 g, mp 155 ℃, tare da yawan amfanin ƙasa na 95%.
Hanyar 2) Furniss BS, Hannaford AJ, Rogers V, et al.Littafin Karatu na Vogel na Chemistry.Longman London da New York.Bugu na huɗu,1978：518.
Ƙara 100 g (0.85 mol) na phenylacetonitrile (2) da 400 ml na hydrochloric acid mai mayar da hankali ga flask na amsawa.A ƙarƙashin motsawa, amsa a 40 ℃ na kimanin minti 40, kuma tada zafin jiki zuwa 50 ℃.Ci gaba da mayar da martani na tsawon mintuna 30.Cool zuwa 15 ℃ da kuma ƙara 400 ml na ruwan sanyi distilled ruwa dropwise.Sanyaya a cikin ruwan wanka na kankara, tace lu'ulu'u.Ƙara m zuwa 50 ml na ruwa kuma motsa sosai don cire phenylacetic acid.Tace da bushe a 50-80 ℃ don samun 95 g na phenylacetamide (1), mp 154-155 ℃, tare da yawan amfanin ƙasa na 82%.Recrystallization tare da ethanol, mp 156 ℃.
Lokacin aikawa: Afrilu-11-2023